Agammaglobulinemia (Rare Diseases of the Immune System) by Alessandro Plebani,Vassilios Lougaris

By Alessandro Plebani,Vassilios Lougaris

This booklet presents an up to date review of agammaglobulinemia, a unprecedented kind of fundamental immunodeficiency that's thought of the prototype of the congenital humoral defects, and that's characterised by means of the absence of peripheral B cells and intensely low serum immunoglobulin degrees. The e-book opens through discussing the hugely orchestrated early B mobilephone improvement within the bone marrow and the genes concerned in response to either human and animal versions. The pathogenesis and medical presentation of X-linked agammaglobulinemia, as a result of mutations within the BTK (Bruton’s tyrosine kinase) gene, are then provided intimately, by way of descriptions of the medical manifestations and molecular foundation of the fewer widespread autosomal recessive and autosomal dominant varieties of agammaglobulinemia.  sufferers’ administration when it comes to breathing problems, gammaglobulin substitute treatment and the capability worth of novel experimental healing suggestions are  mentioned. The book’s ultimate chapters supply a accomplished and up to date description of mutations within the BTK gene, and the expression and serve as of BTK in cells except B cells.

Show description

Read or Download Agammaglobulinemia (Rare Diseases of the Immune System) PDF

Best cell biology books

International Review of Cell and Molecular Biology: 267

Foreign overview of cellphone and Molecular Biology offers present advances and accomplished experiences in phone biology—both plant and animal. Articles deal with constitution and keep watch over of gene expression, nucleocytoplasmic interactions, keep an eye on of cellphone improvement and differentiation, and telephone transformation and progress.

Deep Metazoan Phylogeny: The Backbone of the Tree of Life: New insights from analyses of molecules, morphology, and theory of data analysis

The turning out to be good fortune of molecular equipment has challenged conventional perspectives of animal evolution and a good number of substitute hypotheses are hotly debated this day. For the deep metazoan phylogeny undertaking, information units of hitherto unrivaled caliber and volume have been compiled and analysed with leading edge bioinformatics instruments.

Cancer Stem Cells

A brand new healing method may well holiday the stalemate within the battle on melanoma through focusing on now not all cancerous cells however the small fraction that lie on the root of cancers. Lucie Laplane deals a complete research of melanoma stem telephone thought, according to an unique interdisciplinary method that mixes biology, biomedical historical past, and philosophy.

Lysosomes: Biology, Diseases, and Therapeutics

Discussing contemporary findings, updated study, and novel concepts, the e-book integrates views from pharmacology, toxicology, and biochemistry to demonstrate the potential for lysosomes in drug discovery and improvement. •    Explores simple ideas and houses of lysosomes that permit them to behave as regulators of mobilephone metabolism, healing ambitions, and websites for activation of drug conjugates •    Discusses the position of lysosomes in metabolism, drug concentrating on, apoptosis, melanoma, getting older, irritation, autophagy, metabolism, toxicity, and membrane repair•    Introduces new pathways in healing improvement and new mechanisms in drug improvement

Extra resources for Agammaglobulinemia (Rare Diseases of the Immune System)

Example text

Download PDF sample

Rated 4.80 of 5 – based on 40 votes